Download E-books Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity, Volume 47 (Current Topics in Membranes) PDF

Sodium reabsorbing epithelia play a big function in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step technique: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated via a number of diverse hormones. The sodium channels additionally play an important function in a couple of disorder states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful Diversity presents the 1st in-depth trade of principles bearing on those sodium channels, their law and involvement in basic and pathophysiological occasions.

Key Features
* Summarizes present kingdom of amiloride-sensitive sodium channel field
* Analyzes structure-function of epithelial sodium channels
* Discusses immunolocalization of epithelial sodium channels
* Examines hormonal legislation of sodium channels
* Discusses sodium channels in lymphocytes, kidney, and lung
* Considers mechanosensitivity of sodium channels
* presents rules on sodium channels and illness

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